Physical inactivity is a Cause of Cancer

In one study exploring the lifestyle of people and the incidence of cancer, researchers have demonstrated that a sedentary lifestyle increases the risk of developing cancer. Several literature reviews also support the correlation between physical inactivity and carcinogenesis.

 

The incidence of cancer has increased dramatically throughout the world in recent years, and cancer is a major cause of disease burden. Prevention is key to reducing cancer's incidence, prevalence, and death rate. Protective elements like physical activity, a healthy diet, and a healthy body weight should be strengthened while known risk factors like alcohol and tobacco use should be avoided. It has been demonstrated that sedentary activity raises the incidence and mortality of cancer. Sedentary behavior, which is widely observed in our daily lives, is defined as "any waking behavior characterized by an energy expenditure․ 1.5 metabolic equivalents, while in a sitting, reclining, or lying posture." At the same time, Adults engage in sitting habits for about 8.2 hours every day.

 

The incidence of cancer has a geographical pattern as well as socio-economic signature. Whereas the LMICs display mortality and morbidity patterns that are associated with infections and lack of infrastructure, the situation is quite different for the High-income countries. For instance, in the US, obesity and lifestyle determinants have a major role in the causation and progression of various cancers. In Africa, and many less developed WHO regions, the impacts of poor cancer management, prevention and control infrastructure act in concert to drive the morbidity and mortality associated with cancer. The African cancer landscape has several unique compounding elements. For instance, the roles that infections and culture play have multiple impacts on health seeking, as well as diagnosis and treatment of cancer. Consequently, the delays that arise lead to late presentation for cancer treatment. Furthermore, acting together with poor diagnosis, lack of personnel, and capacity to manage cancer the oncological picture of Africa is in need of multifocal and urgent action.

 

 

What are common sedentary activities?

We are spending an increasing amount of time in high-income countries in front of screens, including TVs, laptops, tablets, and cellphones. Additionally, most of the time that we text, view videos, play online games, browse the web, or post on social media, we do so while seated.

We also drive and use public transportation more and more of the time. And because technology has advanced, a lot of us also spend our days seated at our desks. While many low-income countries have an inherent disadvantage, several of these lifestyle elements are evident in the LMICs. For example, in low-income countries, the expense of diagnosis is unaffordable, while in high-income countries, cancer screening and diagnosis are readily available. However, even if some technology was brought to the LMICs to help with cancer management, it would be useless due to a staffing shortage.

Why is sedentary behavior bad?

Researchers recognize sedentary behavior as a health risk since it can lead to weight gain. Obesity is a risk factor for at least 11 types of cancer. Strong evidence exists that higher level of physical activity reduce the risk of different cancers like breast, colon (intestine), uterus, ovary, prostate, esophagus (food pipe), stomach and bladder.

Over the last thirty to forty years, physical inactivity, sedentary behavior, and overweight or obesity have been identified as the three key modifiable variables associated with an increased risk of cancer. Dietary composition, physical activity, and sedentary behavior all have a significant impact on the incidence of malignancies linked to obesity. According to studies, those who spend a lot of time sitting still are more prone to overfeed themselves. Regretfully, the feeding requires consuming unhealthy snacks and beverages. Further research has revealed that those who follow poor diet plans are more likely to smoke, drink alcohol, and be careless about maintaining their health.

Therefore, it is noteworthy that a sedentary lifestyle affects not only cancer but many other health states as well. Efforts to combat cancer, must target the entire spectrum of relevant issues including the cultural determinants of cancer as well as the legislative environment in which cancer occurs.  

 

Further Reading

1. Kulhánová I, Znaor A, Shield KD, Arnold M, Vignat J, Charafeddine M, Fadhil I, Fouad H, Al‐Omari A, Al‐Zahrani AS et al. (2020) Proportion of cancers attributable to major lifestyle and environmental risk factors in the Eastern Mediterranean region. Int J Cancer 146, 646–656. [PubMed] [Google Scholar]

2. Parkin DM, Boyd L & Walker LC (2011) The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br J Cancer 105, S77–S81. [PMC free article] [PubMed] [Google Scholar]

3. Poirier AE, Ruan Y, Volesky KD, King WD, O'Sullivan DE, Gogna P, Walter SD, Villeneuve PJ, Friedenreich CM & Brenner DR (2019) The current and future burden of cancer attributable to modifiable risk factors in Canada: summary of results. Prev Med 122, 140–147. [PubMed] [Google Scholar]

4. Whiteman DC, Webb PM, Green AC, Neale RE, Fritschi L, Bain CJ, Parkin DM, Wilson LF, Olsen CM, Nagle CM et al. (2015) Cancers in Australia in 2010 attributable to modifiable factors: summary and conclusions. Aust N Z J Public Health 39, 477–484. [PMC free article] [PubMed] [Google Scholar]

5. Ding D, Lawson KD, Kolbe‐Alexander TL, Finkelstein EA, Katzmarzyk PT, van Mechelen W & Pratt M (2016) The economic burden of physical inactivity: a global analysis of major non‐communicable diseases. Lancet 388, 1311–1324. [PubMed] [Google Scholar]

6. Guthold R, Stevens GA, Riley LM & Bull FC (2018) Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population‐based surveys with 1·9 million participants. Lancet Glob Health 6, e1077–e1086. [PubMed] [Google Scholar]

7. NCD Risk Factor Collaboration (NCD‐RisC) (2017) Worldwide trends in body‐mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population‐based measurement studies in 128·9 million children, adolescents, and adults. Lancet 390, 2627–2642. [PMC free article] [PubMed] [Google Scholar]

8. 2018 Physical Activity Guidelines Advisory Committee (2018) 2018 Physical Activity Guidelines Advisory Committee Scientific Report. Department of Health and Human Services, Washington, DC. [Google Scholar]

9. World Cancer Research Fund/American Institute for Cancer Research (2018) Continuous Update Project Expert Report 2018. Diet, Nutrition, Physical Activity and Cancer: A Global Perspective. Retrieved June 1, 2020, from dietandcancerreport.org

10. McTiernan A, Friedenreich CM, Katzmarzyk PT, Powell KE, Macko R, Buchner D, Pescatello LS, Bloodgood B, Tennant B, Vaux‐Bjerke A et al. (2019) Physical activity in cancer prevention and survival: a systematic review. Med Sci Sports Exerc 51, 1252–1261. [PMC free article] [PubMed] [Google Scholar]

11. Tremblay MS, Aubert S, Barnes JD, Saunders TJ, Carson V, Latimer‐Cheung AE, Chastin SFM, Altenburg TM, Chinapaw MJM & on behalf of SBRN Terminology Consensus Project Participants (2017) Sedentary Behavior Research Network (SBRN) – Terminology Consensus Project process and outcome. Int J Behav Nutr Phys Act 14, 75. [PMC free article] [PubMed] [Google Scholar]

12. Jochem C, Wallmann‐Sperlich B & Leitzmann MF (2019) The influence of sedentary behavior on cancer risk: epidemiologic evidence and potential molecular mechanisms. Curr Nutr Rep 8, 167–174. [PubMed] [Google Scholar]

13. American Institute for Cancer Research (2020) Make time + break time. Retrieved June 5, 2020, from https://www.aicr.org/learn‐more‐about‐cancer/infographics/make‐time‐break‐time.html

14. Katzmarzyk PT, Powell KE, Jakicic JM, Troiano RP, Piercy K, Tennant B & 2018 Physical Activity Guidelines Advisory Committee (2018) Sedentary behavior and health: update from the Physical Activity Guidelines Advisory Committee. Med Sci Sports Exerc 51, 1227–1241. [PMC free article] [PubMed] [Google Scholar]

15. Kerr J, Anderson C & Lippman SM (2017) Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence. Lancet Oncol 18, e457–e471. [PMC free article] [PubMed] [Google Scholar]

16. Matthews CE, Chen KY, Freedson PS, Buchowski MS, Beech BM, Pate RR & Troiano RP (2008) Amount of time spent in sedentary behaviors in the United States, 2003–2004. Am J Epidemiol 167, 875–881. [PMC free article] [PubMed] [Google Scholar]

17. World Health Organization (2020) Obesity and overweight fact sheet. Retrieved June 2, 2020, from https://www.who.int/news‐room/fact‐sheets/detail/obesity‐and‐overweight

18. Ligibel JA, Alfano CM, Courneya KS, Demark‐Wahnefried W, Burger RA, Chlebowski RT, Fabian CJ, Gucalp A, Hershman DL, Hudson MM et al. (2014) American Society of Clinical Oncology Position Statement on obesity and cancer. J Clin Oncol 32, 3568–3574. [PMC free article] [PubMed] [Google Scholar]

19. Lauby‐Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F & Straif K (2016) Body fatness and cancer – viewpoint of the IARC Working Group. N Engl J Med 375, 794–798. [PMC free article] [PubMed] [Google Scholar]

20. Avgerinos KI, Spyrou N, Mantzoros CS & Dalamaga M (2019) Obesity and cancer risk: emerging biological mechanisms and perspectives. Metab Clin Exp 92, 121–135. [PubMed] [Google Scholar]

21. Birks S, Peeters A, Backholer K, O'Brien P & Brown W (2012) A systematic review of the impact of weight loss on cancer incidence and mortality. Obes Rev 13, 868–891. [PubMed] [Google Scholar]

22. Sumithran P & Proietto J (2013) The defence of body weight: a physiological basis for weight regain after weight loss. Clin Sci 124, 231–241. [PubMed] [Google Scholar]

23. Snel M, Jonker JT, Schoones J, Lamb H, de Roos A, Pijl H, Smit JWA, Meinders AE & Jazet IM (2012) Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions. Int J Endocrinol 2012, 983814. [PMC free article] [PubMed] [Google Scholar]

24. Schmidt S, Monk JM, Robinson LE & Mourtzakis M (2015) The integrative role of leptin, oestrogen and the insulin family in obesity‐associated breast cancer: potential effects of exercise. Obes Rev 16, 473–487. [PMC free article] [PubMed] [Google Scholar]

25. Thomas RJ, Kenfield SA & Jimenez A (2017) Exercise‐induced biochemical changes and their potential influence on cancer: a scientific review. Br J Sports Med 51, 640–644. [PMC free article] [PubMed] [Google Scholar]

26. Mason C, Xiao L, Duggan C, Imayama I, Foster‐Schubert KE, Kong A, Campbell KL, Wang C‐Y, Alfano CM, Blackburn GL et al. (2013) Effects of dietary weight loss and exercise on insulin‐like growth factor‐I and insulin‐like growth factor‐binding protein‐3 in postmenopausal women: a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 22, 1457–1463. [PMC free article] [PubMed] [Google Scholar]

27. Hadgraft NT, Winkler E, Climie RE, Grace MS, Romero L, Owen N, Dunstan D, Healy G & Dempsey PC (2020) Effects of sedentary behaviour interventions on biomarkers of cardiometabolic risk in adults: systematic review with meta‐analyses. Br J Sports Med. 10.1136/bjsports-2019-101154 [PMC free article] [PubMed] [CrossRef] [Google Scholar]

28. Booth A, Magnuson A, Fouts J & Foster M (2015) Adipose tissue, obesity and adipokines: role in cancer promotion. Horm Mol Biol Clin Investig 21, 57–74. [PubMed] [Google Scholar]

29. Zhao Y, He X, Shi X, Huang C, Liu J, Zhou S & Heng C‐K (2010) Association between serum amyloid A and obesity: a meta‐analysis and systematic review. Inflamm Res 59, 323–334. [PubMed] [Google Scholar]

30. de Boer MC, Wörner EA, Verlaan D & van Leeuwen PAM (2017) The mechanisms and effects of physical activity on breast cancer. Clin Breast Cancer 17, 272–278. [PubMed] [Google Scholar]

31. Carter S, Hartman Y, Holder S, Thijssen DH & Hopkins ND (2017) Sedentary behavior and cardiovascular disease risk: mediating mechanisms. Exerc Sport Sci Rev 45, 80–86. [PubMed] [Google Scholar]

32. Ennour‐Idrissi K, Maunsell E & Diorio C (2015) Effect of physical activity on sex hormones in women: a systematic review and meta‐analysis of randomized controlled trials. Breast Cancer Res 17, 139. [PMC free article] [PubMed] [Google Scholar]

33. de Roon M, May AM, McTiernan A, Scholten RJPM, Peeters PHM, Friedenreich CM & Monninkhof EM (2018) Effect of exercise and/or reduced calorie dietary interventions on breast cancer‐related endogenous sex hormones in healthy postmenopausal women. Breast Cancer Res 20, 81. [PMC free article] [PubMed] [Google Scholar]

34. Chandrasekar T, Yang JC, Gao AC & Evans CP (2015) Mechanisms of resistance in castration‐resistant prostate cancer (CRPC). Transl Androl Urol 4, 365–380. [PMC free article] [PubMed] [Google Scholar]

35. Boyle P, Koechlin A, Bota M, d'Onofrio A, Zaridze DG, Perrin P, Fitzpatrick J, Burnett AL & Boniol M (2016) Endogenous and exogenous testosterone and the risk of prostate cancer and increased prostate‐specific antigen (PSA) level: a meta‐analysis. BJU Int 118, 731–741. [PubMed] [Google Scholar]

36. Dimitrakakis C (2011) Androgens and breast cancer in men and women. Endocrinol Metab Clin North Am 40, 533–547, viii. [PubMed] [Google Scholar]

37. Pasquali R & Oriolo C (2019) Obesity and androgens in women. Front Horm Res 53, 120–134. [PubMed] [Google Scholar]

38. de Sousa CV, Sales MM, Rosa TS, Lewis JE, de Andrade RV & Simões HG (2017) The antioxidant effect of exercise: a systematic review and meta‐analysis. Sports Med 47, 277–293. [PubMed] [Google Scholar]

39. Marseglia L, Manti S, D'Angelo G, Nicotera A, Parisi E, Di Rosa G, Gitto E & Arrigo T (2014) Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci 16, 378–400. [PMC free article] [PubMed] [Google Scholar]

40. Nieman DC & Wentz LM (2019) The compelling link between physical activity and the body's defense system. J Sport Health Sci 8, 201–217. [PMC free article] [PubMed] [Google Scholar]

41. Neilson HK, Conroy SM & Friedenreich CM (2014) The influence of energetic factors on biomarkers of postmenopausal breast cancer risk. Curr Nutr Rep 3, 22–34. [PMC free article] [PubMed] [Google Scholar]

42. El Gendy K, Malcomson FC, Bradburn DM & Mathers JC (2020) Effects of bariatric surgery on DNA methylation in adults: a systematic review and meta‐analysis. Surg Obes Relat Dis 16, 128–136. [PubMed] [Google Scholar]

43. El Gendy K, Malcomson FC, Lara JG, Bradburn DM & Mathers JC (2018) Effects of dietary interventions on DNA methylation in adult humans: systematic review and meta‐analysis. Br J Nutr 120, 961–976. [PubMed] [Google Scholar]

44. Crovesy L, Masterson D & Rosado EL (2020) Profile of the gut microbiota of adults with obesity: a systematic review. Eur J Clin Nutr. 10.1038/s41430-020-0607-6 [PubMed] [CrossRef] [Google Scholar]

45. Gethings‐Behncke C, Coleman HG, Jordao HWT, Longley DB, Crawford N, Murray LJ & Kunzmann AT (2020) Fusobacterium nucleatum in the colorectum and its association with cancer risk and survival: a systematic review and meta‐analysis. Cancer Epidemiol Biomarkers Prev 29, 539–548. [PubMed] [Google Scholar]

46. Guerrero S, López‐Cortés A, Indacochea A, García‐Cárdenas JM, Zambrano AK, Cabrera‐Andrade A, Guevara‐Ramírez P, González DA, Leone PE & Paz‐y‐Miño C (2018) Analysis of racial/ethnic representation in select basic and applied cancer research studies. Sci Rep 8, 13978. [PMC free article] [PubMed] [Google Scholar]

47. Ibraheem A & Polite B (2017) Improving the accrual of racial and ethnic minority patients in clinical trials: time to raise the stakes. Cancer 123, 4752–4756. [PubMed] [Google Scholar]

48. Friedenreich CM, Neilson HK, O'Reilly R, Duha A, Yasui Y, Morielli AR, Adams SC & Courneya KS (2015) Effects of a high vs moderate volume of aerobic exercise on adiposity outcomes in postmenopausal women: a randomized clinical trial. JAMA Oncol 1, 766–776. [PubMed] [Google Scholar]

49. Friedenreich CM, O'Reilly R, Shaw E, Stanczyk FZ, Yasui Y, Brenner DR & Courneya KS (2016) Inflammatory marker changes in postmenopausal women after a year‐long exercise intervention comparing high versus moderate volumes. Cancer Prev Res (Phila) 9, 196–203. [PubMed] [Google Scholar]

50. GBD 2015 Obesity Collaborators , Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, Marczak L, Mokdad AH, Moradi‐Lakeh M et al. (2017) Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med 377, 13–27. [PMC free article] [PubMed] [Google Scholar]

 

Comments

Popular posts from this blog